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Acromegaly

What is Acromegaly?
Acromegaly is a hormonal disorder that results from too much growth hormone (GH) in the body. The pituitary, a small gland in the brain, makes growth hormone (GH). In acromegaly, the pituitary produces excessive amounts of growth hormone (GH). Usually the excess growth hormone (GH) comes from benign, or noncancerous, tumors on the pituitary. These benign tumors are called adenomas.

Acromegaly is most often diagnosed in middle-aged adults, although symptoms can appear at any age. If not treated, acromegaly can result in serious illness and premature death. Acromegaly is treatable in most patients, but because of its slow and often "sneaky" onset, it often is not diagnosed early or correctly. The most serious health consequences of acromegaly are:

• Type 2 diabetes
• High blood pressure
• Increased risk of cardiovascular disease
• Arthritis

Patients with acromegaly are also at increased risk for colon polyps, which may develop into colon cancer if not removed.

When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly. A child's height is determined by the length of the so called long bones in the legs. In response to growth hormone (GH), these bones grow in length at the growth plates - areas near either end of the bone. Growth plates fuse after puberty, so the excessive growth hormone (GH) production in adults does not result in increased height. However, prolonged exposure to excess growth hormone (GH) before the growth plates fuse causes increased growth of the long bones and thus increased height. Pediatricians may become concerned about this possibility if a child's growth rate suddenly and markedly increases beyond what would be predicted by previous growth and how tall the child's parents are.

What is Acromegaly?
Symptoms of Acromegaly
Causes of Acromegaly
How Common is Acromegaly?
How is Acromegaly Diagnosed?
Treatment of Acromegaly
Which Treatment for Acromegaly is Most Effective?

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