History of HGH

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The History of HGH
Here's the story:

The founder of Genentech, a large biotechnology corporation in San Francisco was Herbert Boyer, who was a Nobel Prize winning scientist. He saw the importance of synthetically reproducing the proteins in the body, his company was the first to successfully clone the human gene for insulin. Boyer realized the importance of being the first to synthetically produce HGH so he put his company's best scientists to work on it.

Once the code sequence had been worked out for the human gene that causes the pituitary gland to string together human growth hormone's 191 amino acid chain, the process of reproducing HGH was not too terribly difficult. Once the gene was made it was transplanted into E coli bacteria and was allowed to grow and multiply in a nutrient broth. Genentech's process to produce HGH included a large culture vat that was filled with E-coli bacteria.

In 1985 Genentech successfully synthesized HGH - Human Growth Hormone through recombinant DNA, called Protropin. It was composed of 190 amino acids. HGH - Human Growth Hormone which is 100% identical to pituitary gland secretions is composed 191 amino acids. Though this lack of 1 amino acid did not affect its performance in the body, it kept the door open for competition and marketing rights.

In 1985 Congress passed the "Orphan Drug Act" as a financial incentive for pharmaceutical companies to develop drugs that would be needed by fewer than 200,000 persons. If a company would agree to develop a certain drug they would be given exclusivity for 7 years and so no one else would be able to compete in their market. Then in 1986, Eli Lilly, an Indianapolis based pharmaceutical company, was the first to synthesize a 191 amino acid HGH - Human Growth Hormone molecule which was 100% identical physically, chemically and biologically to the hormone made by the human pituitary gland.

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