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Multiple Sclerosis (MS)

Contents of this Article


Symptoms of MS

Symptoms of Multiple Sclerosis (MS) may be mild or severe, of long duration or short, and may appear in various combinations, depending on the area of the nervous system affected. Complete or partial remission of symptoms, especially in the early stages of the disease, occurs in approximately 70 percent of Multiple Sclerosis (MS) patients.

The initial symptom of Multiple Sclerosis (MS) is often blurred or double vision, red - green color distortion, or even blindness in one eye. Inexplicably, visual problems tend to clear up in the later stages of Multiple Sclerosis (MS). Inflammatory problems of the optic nerve may be diagnosed as retrobulbar or optic neuritis. Fifty-five percent of Multiple Sclerosis (MS) patients will have an attack of optic neuritis at some time or other and it will be the first symptom of Multiple Sclerosis (MS) in approximately 15 percent. This has led to general recognition of optic neuritis as an early sign of Multiple Sclerosis (MS), especially if tests also reveal abnormalities in the patient's spinal fluid.

Most Multiple Sclerosis (MS) patients experience muscle weakness in their extremities and difficulty with coordination and balance at some time during the course of the disease. These symptoms may be severe enough to impair walking or even standing. In the worst cases, Multiple Sclerosis (MS) can produce partial or complete paralysis. Spasticity (the involuntary increased tone of muscles leading to stiffness and spasms) is common, as is fatigue. Fatigue may be triggered by physical exertion and improve with rest, or it may take the form of a constant and persistent tiredness.

Most people with Multiple Sclerosis (MS) also exhibit paresthesias (transitory abnormal sensory feelings such as numbness, prickling, or "pins and needles" sensations), uncommonly, some may also experience pain. Loss of sensation sometimes occurs. Speech impediments, tremors, and dizziness are other frequent complaints. Occasionally, people with Multiple Sclerosis (MS) have hearing loss.

Approximately half of all people with Multiple Sclerosis (MS) experience cognitive impairments such as difficulties with concentration, attention, memory, and poor judgment, but such symptoms are usually mild and are frequently overlooked. In fact, they are often detectable only through comprehensive testing. Patients themselves may be unaware of their cognitive loss - it is often a family member or friend who first notices a deficit. Such impairments are usually mild, rarely disabling, and intellectual and language abilities are generally spared.

Cognitive symptoms occur when lesions develop in brain areas responsible for information processing. These deficits tend to become more apparent as the information to be processed becomes more complex. Fatigue may also add to processing difficulties. Scientists do not yet know whether altered cognition in Multiple Sclerosis (MS) reflects problems with information acquisition, retrieval, or a combination of both. Types of memory problems may differ depending on the individual's disease course (relapsing-remitting, primary-progressive, etc.), but there does not appear to be any direct correlation between duration of illness and severity of cognitive dysfunction.

Depression, which is unrelated to cognitive problems, is another common feature of Multiple Sclerosis (MS). In addition, about 10 percent of patients suffer from more severe psychotic disorders such as manic-depression and paranoia. Five percent may experience episodes of inappropriate euphoria and despair - unrelated to the patient's actual emotional state - known as "laughing/weeping syndrome." This syndrome is thought to be due to demyelination in the brainstem, the area of the brain that controls facial expression and emotions, and is usually seen only in severe cases.

As the disease progresses, sexual dysfunction may become a problem. Bowel and bladder control may also be lost.

In about 60 percent of Multiple Sclerosis (MS) patients, heat - whether generated by temperatures outside the body or by exercise - may cause temporary worsening of many Multiple Sclerosis (MS) symptoms. In these cases, eradicating the heat eliminates the problem. Some temperature sensitive patients find that a cold bath may temporarily relieve their symptoms. For the same reason, swimming is often a good exercise choice for people with Multiple Sclerosis (MS).

The erratic symptoms of Multiple Sclerosis (MS) can affect the entire family as patients may become unable to work at the same time they are facing high medical bills and additional expenses for housekeeping assistance and modifications to homes and vehicles. The emotional drain on both patient and family is immeasurable. Support groups and counseling may help Multiple Sclerosis (MS) patients, their families, and friends find ways to cope with the many problems the disease can cause.

Possible Symptoms of Multiple Sclerosis (MS)

  • Muscle weakness
  • Spasticity
  • Impairment of pain, temperature, touch senses
  • Pain - moderate to severe
  • Ataxia
  • Tremor
  • Speech disturbances
  • Vision disturbances
  • Vertigo
  • Bladder dysfunction
  • Bowel dysfunction
  • Sexual dysfunction
  • Depression
  • Euphoria
  • Cognitive abnormalities
  • Fatigue

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References:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
January 23, 2008
www.ninds.nih.gov/disorders/multiple_sclerosis/detail_multiple_sclerosis.htm

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