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Growth Hormone for the Elderly?

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There is a linear correlation between integrated 24 hour serum growth hormone concentrations (measured at 20 minute or hourly intervals) and the serum IGF-I concentration in normal subjects.1,2 Integrated 24 hour growth hormone concentrations decline with increasing age and are approximately one third lower in healthy men and women more than 55 years old than in men and women 18 to 33; IGF-I concentrations are similarly reduced.1 As indicated by serum IGF-I measurements, however, the decline in growth hormone secretion with age is not universal.

The prevalence of serum IGF-I concentrations below the range found in 20 to 29 year old men and women was 11 percent in the fourth decade of life, 20 percent in the fifth, 22 percent in the sixth, 42 percent in the seventh, and 55 percent in the eighth and ninth. At all ages, the serum level of IGF-I was inversely correlated with adiposity. The declines in growth hormone and IGF-I production and the decrease in muscle mass and increase in adiposity that occur in healthy elderly subjects, and presumably in adults with growth hormone deficiency, have led to attempts to determine whether the administration of growth hormone is beneficial in such people.

In this issue of the Journal, Rudman and colleagues report the effects of the administration of growth hormone three times a week for six months on body composition in healthy 61 to 81 year old men who had serum IGF-I concentrations below those of healthy younger men.

Source:
content.nejm.org

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