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Growth Hormone for the Elderly?

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In this study and in similar studies of men and women with growth hormone deficiency, the administration of growth hormone increased the serum IGF-I concentrations to within the range found in young (less than 30 years old) healthy adults. The healthy older men and the men and women with growth hormone deficiency had increases in lean body mass of 8.8 and 10 percent and decreases in the mass of adipose tissue of 14.4 and 16 percent, respectively, after six months of growth hormone administration. Growth hormone deficient men and women given growth hormone for four months had a 5 percent increase in muscle volume in the thigh and a 7 percent decrease in adipose-tissue volume in the thigh.

Other effects of long term administration of growth hormone on body composition included a 1.6 percent increase in vertebral bone density and 6.6 and 7 percent increases in skin fold thickness. Left ventricular wall mass, measured by echocardiography, did not change. Functional assessments in the men and women with growth hormone deficiency revealed small increases in exercise capacity, isometric strength, and basal metabolic rate.

These measurements were not performed in the healthy older men. The metabolic effects of growth hormone were less well characterized; however, fasting serum glucose and insulin concentrations increased significantly. Fasting serum cholesterol concentrations decreased in the subjects with growth hormone deficiency and did not change in the older men; triglyceride concentrations did not change in either group.

Source:
content.nejm.org

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