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Growth Hormone for the Elderly?

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These studies extend our understanding of the potential benefits of growth hormone administration to body composition and, to a lesser extent, to muscle and metabolic function in adults with an age related decline in growth hormone secretion and in those with disease related growth hormone deficiency. In assessing a possible role for the administration of growth hormone in older adults, however, these studies should be considered preliminary.

Growth hormone can affect carbohydrate metabolism adversely (producing hyperinsulinemia, glucose intolerance, and diabetes mellitus), the musculoskeletal system (producing arthritis and arthralgia), and the cardiovascular system (producing hypertension, edema, and congestive heart failure), as exemplified by acromegaly. Therefore, before the use of growth hormone in healthy older adults can be contemplated, the following questions should be considered.

What are the effects of long term administration of growth hormone on carbohydrate, lipid, and protein metabolism?
Numerous studies of growth hormone administration for a few hours or days have demonstrated both seemingly beneficial and harmful effects. They include impaired glucose uptake (carbohydrate intolerance), increased insulin secretion and insulin resistance, increased serum triglyceride and decreased serum cholesterol concentrations, a decrease in plasma urea levels and urinary nitrogen excretion, and positive nitrogen balance. It is not clear whether the long term administration of growth hormone produces similar effects, or whether the improved metabolism of nutrients observed in animals given growth hormone also occurs in humans.

Source:
content.nejm.org

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