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Growth Hormone for the Elderly?

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This is probably the most important area of growth hormone research, since the more efficient use of substrate is the likely basis for the observed changes in body composition during the administration of growth hormone.

Does long term treatment with growth hormone improve muscle function? Information on this subject is meager, but in 20 adults with growth hormone deficiency, exercise capacity increased in 11, was unchanged in 6, and declined in 3 after four months of treatment with growth hormone.

This aspect of the effects of growth hormone is also of interest to athletes, since pharmacologic doses of growth hormone produced a 12 percent decrease in body fat and a 4 percent increase in fat free weight in highly conditioned exercising men and women 22 to 33 years of age. Growth hormone is said to improve athletic performance, but this claim is far from proved.

If growth hormone is to be given to healthy older adults with diminished production of the hormone, when should its administration begin? If the purpose is to reverse the decline in growth hormone secretion that occurs with aging, then treatment would need to begin in the fourth decade of life in some people.

If it is given, for how long should it be given? Since it is unlikely that the beneficial effects of growth hormone on body composition are lasting, lifelong use would probably be required.

Source:
content.nejm.org

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