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Growth Hormone for the Elderly?

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Because there are so many unanswered questions about the use of growth hormone in the elderly and in adults with growth hormone deficiency, its general use now or in the immediate future is not justified.

A better use of scientific and financial resources would be to determine whether growth hormone is beneficial in patients with severe catabolic illnesses.

Limited information suggests that growth hormone is beneficial in patients with burn injury, sepsis, or renal failure and during prolonged recovery after surgery.

Ideally, short term growth hormone therapy, in conjunction with optimal nutritional and other medical support, may reverse or ameliorate ongoing catabolism, aid in recovery, and shorten the duration of the illness.

Our understanding of growth hormone, its interrelations with other hormones, and its regulation of metabolism is considerable. Although its actions and benefits are fairly clear in children with growth hormone deficiency, they are not at all clear in adults.

The studies of Rudman et al. and other investigators should be viewed as an important beginning in deciphering the actions of growth hormone in adults.

Source:
content.nejm.org

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