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Can Growth Hormone Prevent Aging?

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The administration of growth hormone in older men resulted in a 4.7 kg increase in lean body mass, a 3.5 kg decrease in adipose mass, and an increase of 0.02 g per square centimeter in lumbar spine density; systolic blood pressure and the fasting glucose concentration increased significantly.

The study was not double blind (there was a control group consisting of nine men who received no treatment); there were no assessments of muscle strength, exercise endurance, or quality of life. This study is the basis for claims that growth hormone reverses aging. My editorial accompanying the article by Rudman et al. concluded that such studies in older adults "should be viewed as an important beginning," with the implication that subsequent studies would determine the benefits and risks of growth hormone treatment in older adults.

A recent double blind, placebo controlled study involving 27 women and 34 men, 68 to 88 years of age, who were given growth hormone or placebo for 6.5 months confirmed the effects of growth hormone on body composition; there was no change in muscle strength or maximal oxygen uptake during exercise in either group. This study corroborated the findings of a study by Papadakis et al. involving 52 healthy men, 70 to 85 years of age, who were given placebo or growth hormone for six months.

Not mentioned on the "antiaging" Web sites is a study of 18 healthy men, 65 to 82 years of age, who underwent progressive strength training for 14 weeks, followed by an additional 10 weeks of strength training plus either growth hormone or placebo. In that study, resistance exercise training increased muscle strength significantly; the addition of growth hormone did not result in any further improvement. Going to the gym is beneficial and certainly cheaper than growth hormone. The second consideration is the effect of long term administration of growth hormone.

Source:
The New England Journal of Medicine
1990
content.nejm.org

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