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Can Growth Hormone Prevent Aging?

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It is not known whether long term administration of growth hormone in the elderly is potentially harmful, particularly with regard to the risk of cancer, given that older age is associated with an increased incidence of cancer.

In 152 healthy men, the relative risk of the subsequent development of prostate cancer was increased by a factor of 4.3 among men who had serum concentrations of insulin-like growth factor 1 in the highest quartile, as compared with those whose concentrations were in the lowest quartile.

This finding does not demonstrate causality by growth hormone or insulin-like growth factor 1, but it does raise concern about giving older men growth hormone, which increases serum concentrations of insulin-like growth factor 1.

The third matter of concern is the potential misuse of health care resources. Growth hormone replacement in growth hormone deficient adults with pituitary disease is expensive, costing between $7,500 and $10,000 yearly.

It is not known precisely how much growth hormone is prescribed for "off label" uses, but estimates suggest that one third of prescriptions for growth hormone in the United States are for indications for which it is not approved by the Food and Drug Administration.

Source:
The New England Journal of Medicine
1990
content.nejm.org

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