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Can Growth Hormone Prevent Aging?

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How many of these prescriptions are reimbursed inappropriately by third party payers? It is often difficult to obtain third party payment for growth hormone replacement for adults with documented hypopituitarism and growth hormone deficiency, hence the concern about the inappropriate allocation of resources and denial of reimbursement for appropriate patients in whom growth hormone replacement is beneficial.

Studies that have followed the 1990 report by Rudman et al. confirm the effects of growth hormone on body composition but do not show improvement in function. In contrast, resistance training improves muscle strength and function, indicating that real effort is beneficial. There is no current "magic bullet" medication that retards or reverses aging.

It remains to be determined whether growth hormone secretagogues that consistently increase endogenous production of growth hormone are beneficial in the elderly. Antiaging therapy with growth hormone has not yet been proved effective according to objective outcome criteria.

Dr. Vance has reported receiving grant support and consulting fees from Pharmacia and grant support from Eli Lilly and Genentech.

Source:
The New England Journal of Medicine
1990
content.nejm.org

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