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Can Growth Hormone Prevent Aging?

References
Source Information:
From the Department of Medicine, University of Virginia Medical Center, Charlottesville.

References
1. Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990;323:1-6.

2. Vance ML. Growth hormone for the elderly? N Engl J Med 1990;323:52-54.

3. Blackman MR, Sorkin JD, Munzer T, et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 2002;288:2282-2292.

4. Papadakis MA, Grady D, Black D, et al. Growth hormone replacement in older men improves body composition but not functional ability. Ann Intern Med 1996;124:708-716.

5. Taaffe DR, Pruitt L, Reim J, et al. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 1994;79:1361-1366.

6. Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor 1 and prostate cancer risk: a prospective study. Science 1998;279:563-566.

Related Letters:
Human Growth Hormone and Aging
Mahmud K., Vance M. L.
N Engl J Med 2003; 348:2256-2257, May 29, 2003

This article has been cited by other articles:
Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., Cohen, P. (2008). Functionally significant insulin-like growth factor 1 receptor mutations in centenarians. Proc. Natl. Acad. Sci. USA 105: 3438-3442

Liu, H., Bravata, D. M., Olkin, I., Nayak, S., Roberts, B., Garber, A. M., Hoffman, A. R. (2007). Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy Elderly. ANN INTERN MED 146: 104-115

Iruthayanathan, M., Zhou, Y.-H., Childs, G. V. (2005). Dehydroepiandrosterone Restoration of Growth Hormone Gene Expression in Aging Female Rats, in Vivo and in Vitro: Evidence for Actions via Estrogen Receptors. Endocrinology 146: 5176-5187

Perls, T. T., Reisman, N. R., Olshansky, S. J. (2005). Provision or Distribution of Growth Hormone for "Antiaging": Clinical and Legal Issues. JAMA 294: 2086-2090

Davenport, R. J. (2004). Growing Pains. Sci Aging Knowl Environ 2004: ns5-ns5

Perls, T. T. (2004). Anti-Aging Medicine: The Legal Issues: Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade--More Dangerous Than Ever. J. Gerontol. A Biol. Sci. Med. Sci. 59: B682-B691

Binstock, R. H. (2004). Anti-Aging Medicine: The History: Anti-Aging Medicine and Research: A Realm of Conflict and Profound Societal Implications. J. Gerontol. A Biol. Sci. Med. Sci. 59: B523-B533

Coles, L. S. (2004). Aging: The Reality: Demography of Human Supercentenarians. J. Gerontol. A Biol. Sci. Med. Sci. 59: B579-B586

Mahmud, K., Vance, M. L. (2003). Human Growth Hormone and Aging. NEJM 348: 2256-2257

Source:
The New England Journal of Medicine
1990
content.nejm.org

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